ANCA-Positive Vasculitis

C-ANCA Positive Vasculitis in a Case of Amyloidosis

ANCA-positive vasculitis: Clinical implications of ANCA types and titers.

INTRODUCTION Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disease that can affect multiple organs, the kidney being one of the most affected. Apart from the diagnostics value of ANCA, they have also been advocated as biomarkers of the disease activity. Recently, the genetic changes found in polyangiitis associated with serine-protease proteinase 3 (PR3)-ANC...

Diagnosing ANCA-associated vasculitis in ANCA positive patients

Currently no validated diagnostic system for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is available. Therefore, diagnosing AAV is often challenging. We aimed to identify factors that lead to a clinical diagnosis AAV in ANCA positive patients in a teaching hospital in The Netherlands.In this study, all patients that tested positive for ANCA proteinase 3 (PR3) and/or ...

ANCA positive vasculitis in systemic sclerosis

Two sisters with ANCA positive vasculitis.

samples were tested by both solid phase assays. None of the 25 serum samples tested was positive for the anti-29 kilodalton ELISA. Four out of 27 serum samples were positive for the anti-myeloperoxidase ELISA and negative for antinuclear antibody testing. Anti-myeloperoxidase positive serum samples were P-ANCA positive (n=3) or immunofluorescence negative (n= 1). No marked hypergammaglobulinaem...